When your frog is clearly sick with an illness, most diseases are incurable from home. You can treat some diseases with special chemicals, but they're not all that cheap and take professional care. The best answer is always to take your frog to the veterinarian.
If you know your frog is truly sick (believe me, it's pricy to take your frog to the vet), you will want to give your vet a call. See if the technician over the phone recognizes any of your frog's symptoms after listing them all. Follow their advice, and set up an appointment as soon as possible. If you cannot get your frog to the animal hospital that very day, make your frog as comfortable as possible. My frog is a tree frog, so I doubled the heat and lighting, kept him moist, and checked on him every few hours.
To take your frog to the veterinarian, you will need to be able to transport them in a way that's most comfortable for your frog. Unless you have a small animal keeper, you will need to use a plastic cup with Seran wrap over the top. Secure the wrap with a rubber band and punch plenty of holes in the top of the cup using a toothpick or pencil. Always keep a moistened (not soaking wet) paper towl in the bottom of the cup for a refreshing retreat for your frog.
When choosing the best veterinarian for your frog, you will need to go in the phonebook or online and find out which animal hospital is nearest to you, and which animals they serve. If they don't serve small animals, don't call, because they probably won't be able to help you with your frog.
When handling sick frogs, make sure you read my Handling Frogs article.
Also see my Frog Health and Diseases article. This will give very basic information on frogs' diseases.
Another thing to do to get top-quality amphibian veterinary services is to call the pet store you bought your frog from. Just ask them what they think and if they have any recommendations for a local vet, because pet stores have to take their animals to the vet once in a while, too. I did this and found the most wonderful animal hospital.
Remember, your veterinarian only has so many supplies and resources. Your frog may be incorrectly diagnosed, or may not get diagnosed at all. Do what you can for your frog that will make him more comfortable, including administering faithfully any medications or treatments the vet prescribes. Don't lose heart if your frog does not make it through his illness. My first frog did not, even though I took him to a vet and did all I could for him (read my In Memory of Jungle article).
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